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Solutions

FH-EARLY Solutions: Smarter Tools for Early Action.

We’re introducing three powerful, interconnected tools that make it easier, faster, and more precise to diagnose and manage familial hypercholesterolaemia (FH). Built with input from patients, families and clinicians, these innovations are helping shape the future of cardiovascular health.

The Chip Array: Fast, Affordable Genetic Diagnosis

What is it?

The chip array is a compact, high-powered diagnostic tool that can scan your DNA for thousands of genetic markers linked to FH — all in one go. Think of it as a medical “microchip” that helps identify the inherited causes of high cholesterol.

What does it do?

  • Detects both monogenic (single-gene) and polygenic (multiple-gene) forms of FH.
  • Identifies patients who may be missed by traditional clinical assessments.
  • Works quickly, affordably, and can be rolled out worldwide using standard lab equipment.

Why it matters:

Today, many people with FH go undiagnosed until much later in life. This chip speeds up the process, catching risks earlier — especially in children and young adults — so they can get the care they need sooner.

The Signature Biomarker Assay: Personalised Risk & Treatment

What is it?

A biomarker is a biological signal — something measurable in your body that tells us about your health. This signature biomarker assay looks at how your white blood cells (leukocytes) take in and store fats, revealing how your body handles cholesterol at the cellular level.

What does it do?

  • Measures 28 detailed cellular indicators linked to cholesterol metabolism.
  • Helps identify people who are at high risk of heart disease — even if their genetics don’t show it.
  • Supports smarter, more personalised treatment choices from day one.

Why it matters:

Not all people with FH respond the same way to treatment. This test helps clinicians decide who needs stronger therapies and who can do well with standard options — avoiding guesswork and getting better results, faster.

Integrative Precision Health Profiling Tool: Explainable AI for Real-World Decisions

What is it?

This tool uses explainable artificial intelligence (AI) to combine and analyse a wide range of data — from your genetics and lab results to lifestyle factors and imaging. Unlike traditional “black box” AI, this system shows you how it reached its conclusions, in ways both patients and clinicians can understand.

What does it do?

  • Predicts individual risk of heart disease by integrating genetics, biology, and clinical data.
  • Offers clear, personalised recommendations for treatment and lifestyle changes.
  • Presents results using easy-to-read visuals and explanations — no technical jargon.

Why it matters:

This tool bridges the gap between complex science and everyday healthcare. It gives patients real insight into their risks and options — enabling shared decisions with their care team based on trust and transparency.

Putting it All Together

These three tools work best in combination, but each is powerful on its own:

  • The chip array finds those at risk, early.
  • The biomarker assay pinpoints how best to treat them.
  • The AI tool helps make sense of it all — and empowers people to act.

Together, they offer a new standard in FH care — proactive, personalised, and people-centred.

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The project is funded by the EU
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or HaDEA. Neither the European Union nor the granting authority can be held responsible for them.
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